Home • Life Sciences and Research Solutions • Educational Resources • Peer-Reviewed Publications Repository - Aperio VERSA Peer-Reviewed Publications Repository - Aperio VERSA Image Long-term Exposure To House Dust Mites Accelerates Lung Cancer Development In Mice Publication Year: 2023 Country: USA PMID: N/A Publication: J Exp Clin Cancer Res (2023) 42:26 https://doi.org/10.1186/s13046-022-02587-9 Institute: Division of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0663, USA. Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. The State Key Laboratory of Respiratory Disease, Guang- dong Provincial Key Laboratory of Allergy and Clinical Immunology, Center for Immunology, Inflammation and Immune-Mediated Disease, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea. Networked Biomedical Research Center for Hepatic and Digestive Diseases (CIBERehd), Hospital General Universitario de Alicante, Alicante, Spain. Alicante Institute of Health and Biomedical Research (ISABIAL), Alicante, Spain. Cell IDx Inc, San Diego, CA, USA. Division of Pediatric Allergy, Immunology, and Rheumatology, Rady Children’s Hospital of San Diego, University of California San Diego, La Jolla, CA, USA. Tissue Technology Shared Resource, Moores Cancer Center, University of California San Diego, La Jolla, CA, USA. Department of Pathology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, USA. Division of Endocrinology, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, USA. Medical Research Service, Veteran Affairs San Diego Healthcare System, San Diego, CA, USA. Instrument: Aperio VERSA Authors: Dongjie Wang, Wen Li, Natalie Albasha, Lindsey Grifn, Han Chang, Lauren Amaya, Sneha Ganguly, Liping Zeng, Bora Keum, José M. González Navajas, Matt Levin, Zohreh AkhavanAghdam, Helen Snyder, David Schwartz, Ailin Tao, Laela M. Boosherhri, Hal M. Hofman, Michael Rose, Monica Valeria Estrada, Nissi Varki, Scott Herdman, Maripat Corr, Nicholas J. G. Webster, Eyal Raz and Samuel Bertin Study Goals: Individuals with certain chronic inflammatory lung diseases have a higher risk of developing lung cancer (LC). However, the underlying mechanisms remain largely unknown. Here, we hypothesized that chronic exposure to house dust mites (HDM), a common indoor aeroallergen associated with the development of asthma, accelerates LC development through the induction of chronic lung inflammation (CLI). Keywords: Lung cancer, Kras, Urethane, House dust mites, Chronic inflammation, NLRP3, IL-1β, CCL2, Macrophages, Tumor microenvironment Image Integration of tumor extrinsic and intrinsic features associates with immunotherapy response in non-small cell lung cancer. Publication Year: 2022 Country: USA PMID: 35831288 Publication: Nat Commun. 2022;13(1):4053. Published 2022 Jul 13. doi:10.1038/s41467-022-31769-4 Institute: Tempus Labs, Inc., Chicago, IL 60654 USA Department of Pathology, University of Chicago, Chicago, IL 60637 USA Instrument: Aperio VERSA Authors: Lau D, Khare S, Stein MM, et al. Study Goals: To investigate whether cytotoxic CD4+ T cells mediate anti-tumor activity via HLA-II on tumor cells and augment HLA-I-dependent cytotoxic CD8+ T cell interactions to drive ICB response in NSCLC. Keywords: Tumour biomarkers, Non-small-cell lung cancer, Data integration, Tumour immunology, Translational research Image UltraPlex Hapten-Based Multiplexed Fluorescent Immunohistochemistry. Publication Year: 2022 Country: USA PMID: 34331291 Publication: Methods Mol Biol. 2021;2350:267-287. doi:10.1007/978-1-0716-1593-5_17 Institute: Cell IDx, San Diego, CA, USA. Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL, USA. Ludwig Center for Metastasis Research, The University of Chicago, Chicago, IL, USA. Instrument: Aperio VERSA Authors: Levin M, Flor AC, Snyder H, Kron SJ, Schwartz D. Study Goals: To describe the UltraPlex method for multiplexed two-dimensional fluorescent immunohistochemistry Keywords: Antibody; Hapten; Immunofluorescence; Immunohistochemistry; Microscopy; Multiplex imaging. Image Deep Learning of Histopathology Images at the Single Cell Level. Publication Year: 2021 Country: USA PMID: PMC8461055 Publication: Frontiers in Artificial Intelligence. 2021;4. doi:10.3389/frai.2021.754641 Institute: Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL Instrument: Aperio VERSA Authors: Lee K, Lockhart JH, Xie M, et al. Study Goals: To systematically review the various machine learning methods with a focus on cell-level analysis. Keywords: Aperio VERSA, histopathology image analysis, deep learning, image data labeling, cell type classification, tumor immune microenvironment, tumor heterogeneity Image NLRC4 inflammasome–dependent cell death occurs by a complementary series of three death pathways and determines lethality in mice. Publication Year: 2021 Country: China PMID: PMC8535822 Publication: Science Advances. 2021;7(43). doi:10.1126/sciadv.abi9471 Institute: State Key Laboratory of Cellular Stress Biology, Xiang’an Hospital of Xiamen University, Cancer Research Center of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102, Instrument: Aperio VERSA Authors: Zhang P, Liu Y, Hu L, et al. Study Goals: To study NLRC4-mediated cell death and tissue damage Keywords: Aperio VERSA Image In Vivo Measurement of Granzyme Proteolysis from Activated Immune Cells with PET. Publication Year: 2021 Country: USA PMID: PMC8554823 Publication: ACS Central Science. 2021;7(10):1638-1649. doi:10.1021/acscentsci.1c00529 Institute: Department of Radiology and Biomedical Imaging Instrument: Aperio VERSA Authors: Zhao N, Bardine C, Lourenço AL, et al. Study Goals: To evaluate whether granzyme biochemistry can be assessed in vivo using an imaging modality that can be scaled vertically into human subjects Keywords: Aperio VERSA Image Interdependence of neural network dysfunction and microglial alterations in Alzheimer’s disease-related models. Publication Year: 2021 Country: USA PMID: PMC8561005 Publication: iScience. 2021;24(11):103245. doi:10.1016/j.isci.2021.103245 Institute: Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco Instrument: Aperio VERSA Authors: Das M, Mao W, Shao E, et al. Study Goals: To understand whether Increased expression of TREM2 seems to support microglial activities that counteract AD related network dysfunction Keywords: Aperio VERSA For Research Use Only. Not for use in diagnostic procedures. 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