Home • Life Sciences and Research Solutions • Educational Resources • Peer-Reviewed Publications Repository Peer-Reviewed Publications Repository The Leica Biosystems Life Science peer-reviewed publication repository offers a method for building a bibliography of scientific publications referencing Leica Biosystems Life Sciences products. Contact Our Expert Instrument - BOND RX Image BOND RX The BOND RX high-throughput research stainer delivers speed and flexibility for IHC, ISH, and multiplexing staining with either chromogenic or fluorescence markers. View All BOND RX Publications A physical wiring diagram for the human immune system. Publication Year: 2022 Country: USA PMID: 35922511 Publication: Nature. 2022;608(7922):397-404. doi:10.1038/s41586-022-05028-x Authors: Shilts J, Severin Y, Galaway F, et al. Study Goals: To systematically map the direct protein interactions across a recombinant library that encompasses most of the surface proteins that are detectable on human leukocytes Keywords: Immunochemistry, Multicellular systems BiTE secretion from in situ-programmed myeloid cells results in tumor-retained pharmacology Publication Year: 2022 Country: USA PMID: PMC8840964 Publication: J Control Release. 2022;342:14-25. doi:10.1016/j.jconrel.2021.12.029 Authors: Hao S, Inamdar VV, Sigmund EC, et al. Study Goals: This study developed targeted nanocarriers that can deliver in vitro-transcribed mRNA encoding BiTEs to host myeloid cells - a cell type that is actively recruited into the tumor microenvironment. Keywords: Bi-specific T-cell engagers (BiTEs); In situ gene therapy; Nanotechnology. Instrument - Aperio GT 450 Image Aperio GT 450 Scale up Digital Pathology operations by increasing throughput in high volume research pathology laboratories, with 450 slide capacity and rapid scanning. View All Aperio GT 450 Publications Involvement of Innate Immune Receptors in the Resolution of Acute Hepatitis B in Woodchucks. Publication Year: 2022 Country: USA PMID: PMC8340647 Publication: Frontiers in Immunology. 2021;12. doi:10.3389/fimmu.2021.713420 Authors: Suresh M, Li B, Murreddu MG, Gudima SO, Menne S. Study Goals: To show that the the differential expression of PRRs during resolution and persistence of WHV infection emphasizes their importance in the ultimate viral control during AHB that is impaired during CHB. Keywords: Aperio GT450 Cholecystokinin-B Receptor-Targeted Nanoparticle for Imaging and Detection of Precancerous Lesions in the Pancreas. Publication Year: 2021 Country: USA PMID: PMC8698999 Publication: Biomolecules. 2021;11(12):1766. doi:10.3390/biom11121766 Authors: Smith JP, Cao H, Edmondson EF, Dasa SSK, Stern ST. Study Goals: To demonstrate the detection of early precancerous lesions (PanINs) in genetically engineered mice. Keywords: Aperio GT450, pancreatic cancer; cholecystokinin receptor; fluorescence; imaging; PanINs Instrument - BOND RXm Image BOND RXm Deliver reproducible, quality slides and eliminate time spent on manual staining with the BOND RXm fully automated benchtop stainer for IHC, ISH, and emerging tests. View All BOND RXm Publications Fatal Neurodissemination and SARS-CoV-2 Tropism in K18-hACE2 Mice Is Only Partially Dependent on hACE2 Expression Publication Year: 2022 Country: USA PMID: PMC8955233 Publication: Viruses. 2022;14(3):535. doi:10.3390/v14030535 Authors: Carossino M, Kenney D, O’Connell AK, et al. Study Goals: To analyse neuroinvasion and neurodissemination in humans call into question the translational relevance of this model. Keywords: BOND RXm, translational animal model; comparative pathology; immunohistochemistry; in situ hybridization; viral pathogenesis; transmission electron microscopy; in vivo imaging Intranasal type I interferon treatment is beneficial only when administered before clinical signs onset in the SARS-CoV-2 hamster model Publication Year: 2021 Country: France PMID: PMC8376007 Publication: PLOS Pathogens. 2021;17(8):e1009427. doi:10.1371/journal.ppat.1009427 Authors: Bessière P, Wasniewski M, Picard-Meyer E, et al. Study Goals: To investigate whether early type I IFN treatment is beneficial, while late interventions are ineffective, although not associated with signs of enhanced disease. Keywords: BOND RXm Instrument - HistoCore NANOCUT R Image Histocore NANOCUT R Automated Rotary Microtome View All Histocore NANOCUT R Publications Unravelling New Roles Of A Tomato SIN3 Homolog In Leaf Polarity Mediated By Auxin Signaling And Leaf Growth-Related Transcription Factors Publication Year: 2022 Country: China PMID: N/A Publication: Scientia Horticulturae. 2022;300:111055. doi:10.1016/j.scienta.2022.111055 Authors: Liu Y, Fei S, Chen Y, et al. Study Goals: To explore a new role of SIN3 in leaf polarity and provide a possible action mechanism of SlSIN3a in leaf development. Keywords: Tomato, SIN3, Leaf development, Adaxial–abaxial polarity, Leica HistoCore NANOCUT R A Previously Unknown Feeding Mode In Millipedes And The Convergence Of Fluid Feeding Across Arthropods Publication Year: 2022 Country: Germany PMID: PMC8849289 Publication: Science Advances. 2022;8(7). doi:10.1126/sciadv.abm0577 Authors: Moritz L, Borisova E, Hammel JU, Blanke A, Wesener T. Study Goals: To trace the evolution of suctorial feeding in arthropods. Keywords: Arthropods, Diplopoda, Pumping chamber, Fluid feeding, Leica HistoCore NANOCUT R Instrument - Aperio CS2 Image Aperio CS2 5 slide capacity, brightfield scanner for low throughput, high quality scans. 2x3 slide option available for large slides. View All Aperio CS2 Publications Comparison of Osteosarcoma Aggregated Tumour Models with Human Tissue by Multimodal Mass Spectrometry Imaging. Publication Year: 2021 Country: UK PMID: PMC8073208 Publication: Metabolites. 2021;11(8):506. doi:10.3390/metabo11080506 Authors: Flint LE, Hamm G, Ready JD, et al. Study Goals: To demonstrate that MALDI MSI as a promising tool for the investigation of histologically heterogeneous atherosclerotic plaques. Keywords: Aperio CS2 Cortical Electrical Stimulation Ameliorates Traumatic Brain Injury-Induced Sensorimotor and Cognitive Deficits in Rats. Publication Year: 2021 Country: Taiwan PMID: PMC8236591 Publication: Frontiers in Neural Circuits. 2021;15. doi:10.3389/fncir.2021.693073 Authors: Kuo C-W, Chang M-Y, Liu H-H, et al. Study Goals: To demonstrate a novel CES scheme with a theta-burst stimulation (TBS) protocol to identify the therapeutic potential of cortical electrical stimulation (CES) in a weight drop-induced rat model of traumatic brain injury (TBI). Keywords: Aperio CS2 Instrument - Aperio VERSA Image Aperio VERSA The flexible Digital Pathology research scanner for brightfield, fluorescence & FISH whole slide imaging. View All Aperio VERSA Publications Integration of tumor extrinsic and intrinsic features associates with immunotherapy response in non-small cell lung cancer. Publication Year: 2022 Country: USA PMID: 35831288 Publication: Nat Commun. 2022;13(1):4053. Published 2022 Jul 13. doi:10.1038/s41467-022-31769-4 Authors: Lau D, Khare S, Stein MM, et al. Study Goals: To investigate whether cytotoxic CD4+ T cells mediate anti-tumor activity via HLA-II on tumor cells and augment HLA-I-dependent cytotoxic CD8+ T cell interactions to drive ICB response in NSCLC. Keywords: Tumour biomarkers, Non-small-cell lung cancer, Data integration, Tumour immunology, Translational research UltraPlex Hapten-Based Multiplexed Fluorescent Immunohistochemistry. Publication Year: 2022 Country: USA PMID: 34331291 Publication: Methods Mol Biol. 2021;2350:267-287. doi:10.1007/978-1-0716-1593-5_17 Authors: Levin M, Flor AC, Snyder H, Kron SJ, Schwartz D. Study Goals: To describe the UltraPlex method for multiplexed two-dimensional fluorescent immunohistochemistry Keywords: Antibody; Hapten; Immunofluorescence; Immunohistochemistry; Microscopy; Multiplex imaging. Instrument - Imagescope/Aperio Software Image Aperio ImageScope Downloadable viewing software—experience rapid access to crisp, true-color digital slide images. View All Aperio ImageScope Publications Computational Model-Based Estimation of Mouse Eyeball Structure From Two-Dimensional Flatmount Microscopy Images. Publication Year: 2021 Country: USA PMID: PMC8088229 Publication: Translational Vision Science & Technology. 2021;10(4):25. doi:10.1167/tvst.10.4.25 Authors: Li H, Yu H, Kim Y-K, et al. Study Goals: To investigate a a new method for estimating the three-dimensional (3D) eyeball sphere from two-dimensional tissue flatmount microscopy images Keywords: Aperio CS2 Comparison of Osteosarcoma Aggregated Tumour Models with Human Tissue by Multimodal Mass Spectrometry Imaging. Publication Year: 2021 Country: UK PMID: PMC8073208 Publication: Metabolites. 2021;11(8):506. doi:10.3390/metabo11080506 Authors: Flint LE, Hamm G, Ready JD, et al. Study Goals: To demonstrate that MALDI MSI as a promising tool for the investigation of histologically heterogeneous atherosclerotic plaques. Keywords: Aperio CS2 For Research Use Only. 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