From Diagnosis to Treatment - Part 3 of 4, Diagnosis of Breast Cancer with H&E and Immunohistochemistry Stains Thomas Haas D.O., FCAP In the case of Breast Cancer, the patient’s cancer is usually detected by a mammogram or palpitation of an experienced Physician. However, these first indications that something is wrong must be confirmed by a more scientific approach. Usually what follows is an actual biopsy; a sample of the tissue in question is removed from the person. Once a tumor is confirmed from the biopsy, then a more radical surgical approach may be necessary or other treatments are performed. Part 3 of the series addresses the importance of proper H&E/ICH sections and staining for diagnosis of breast tumors. A view of optimization and controls for prognostic markers will be examined, and brief overview of IHC diagnosis and treatment will presented. Learning Objectives Discuss the importance of good H&E / IHC sections, and differences in the pathologist’s evaluation of core versus whole-section specimens. Understand the differential diagnosis of types of breast tumors. To view a good optimization of the antibody as an essential part of laboratory practice. Examine a variety of controls for prognostic (graded) IHC markers such as ER/PR/ HER2 . A brief overview of the next steps after IHC diagnosis and treatment. About the presenter Thomas Haas , D.O., FCAP Dr. Thomas Haas is an attending Pathologist and Director of Molecular Pathology at Mercy Health Systems, Janesville, Wisconsin. He received his Doctor of Osteopathic Medicine from Des Moines University. His daily responsibilities involve anatomic, cytologic, and clinical pathology in a community hospital and system reference laboratory, with participation in tumor board and medical education conferences. His areas of interest include the development of immunohistochemistry panels for tumor diagnosis, molecular pathology, and histotechnology education for the National Society for Histotechnology (NSH). Dr. Haas is board certified in Anatomic and Clinical Pathology. Leica Biosystems Knowledge Pathway content is subject to the Leica Biosystems website terms of use, available at: Legal Notice. The content, including webinars, training presentations and related materials is intended to provide general information regarding particular subjects of interest to health care professionals and is not intended to be, and should not be construed as, medical, regulatory or legal advice. The views and opinions expressed in any third-party content reflect the personal views and opinions of the speaker(s)/author(s) and do not necessarily represent or reflect the views or opinions of Leica Biosystems, its employees or agents. Any links contained in the content which provides access to third party resources or content is provided for convenience only. For the use of any product, the applicable product documentation, including information guides, inserts and operation manuals should be consulted. Copyright © 2024 Leica Biosystems division of Leica Microsystems, Inc. and its Leica Biosystems affiliates. All rights reserved. LEICA and the Leica Logo are registered trademarks of Leica Microsystems IR GmbH. If you have viewed this educational webinar, training or tutorial on Knowledge Pathway and would like to apply for continuing education credits with your certifying organization, please download the form to assist you in adding self-reported educational credits to your transcript. Apply for self-reported educational credits Get Knowledge Pathway updates delivered directly to your inbox. Abonnez-vous aujourd'hui ! We are looking for more great writers to feature here. Send us a submission and we’ll be in touch! Send your writing! SHARE Facebook Twitter LinkedIn Email
In the case of Breast Cancer, the patient’s cancer is usually detected by a mammogram or palpitation of an experienced Physician. However, these first indications that something is wrong must be confirmed by a more scientific approach. Usually what follows is an actual biopsy; a sample of the tissue in question is removed from the person. Once a tumor is confirmed from the biopsy, then a more radical surgical approach may be necessary or other treatments are performed. Part 3 of the series addresses the importance of proper H&E/ICH sections and staining for diagnosis of breast tumors. A view of optimization and controls for prognostic markers will be examined, and brief overview of IHC diagnosis and treatment will presented.
