ホーム • ライフサイエンス向けソリューション • 教育資料 • Peer-Reviewed Publications Repository - BOND RX Peer-Reviewed Publications Repository - BOND RX Image Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and immunothrombosis. Publication Year: 2022 Country: USA PMID: PMC9173818 Publication: Proc Natl Acad Sci U S A. 2022;119(21):e2202012119. doi:10.1073/pnas.2202012119 Institute: Department of Microbial Infection and Immunity, The Ohio State University College of Medicine, Columbus, OH , 43210; Neuroscience graduate program, The Ohio State University, Columbus, OH , 43210; Infectious Diseases Institute, The Ohio State University, Columbus, OH , 43210; Faculty of Pharmacy, Helwan University, Cairo,11731 Egypt; Department of Veterinary Biosciences, The Ohio State University, Columbus, OH , 43210; Department of Biomedical Informatics, The Ohio State University, Columbus, OH , 43210; Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children’s Hospital, Columbus, OH , 43205; Department of Pathology, The Ohio State University, Columbus, OH , 43210; Division of Digestive and Liver Diseases and Center for Human Development, Department of Medicine, Columbia University, New York, NY , 10027; Department of Microbiology and Immunology, Emory University, Atlanta, GA , 30322; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA , 30322; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA , 30322; Department of Neuroscience, Chronic Brain Injury Discovery Theme, The Ohio State University, Columbus, OH , 43210; Center for Microbial Pathogenesis, Abigail Wexner Research Institute at Nationwide Children’s Hospital, Columbus, OH , 43205; Center for Informatics Science, Nile University, Giza, 12525, Egypt; Department of Neurological Surgery, The Ohio State University, Columbus, OH , 43210 Instrument: BOND RX Authors: Eltobgy MM, Zani A, Kenney AD, et al. Study Goals: To investigate the fundamental roles for the noncanonical inflammasome molecule Caspase-4/11 in promoting pathological inflammatory and prothrombotic pathways in severe acute respiratory syndrome coronavirus 2 (SARS–CoV-2) infections Keywords: innate immunity, SARS–CoV-2, thrombosis Image A physical wiring diagram for the human immune system. Publication Year: 2022 Country: USA PMID: 35922511 Publication: Nature. 2022;608(7922):397-404. doi:10.1038/s41586-022-05028-x Institute: Cell Surface Signalling Laboratory, Wellcome Sanger Institute, Cambridge, UK. Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland. Cellular Genetics Programme, Wellcome Sanger Institute, Cambridge, UK. Department of Biology, Hull York Medical School, York Biomedical Research Institute, University of York, York, UK. Instrument: BOND RX Authors: Shilts J, Severin Y, Galaway F, et al. Study Goals: To systematically map the direct protein interactions across a recombinant library that encompasses most of the surface proteins that are detectable on human leukocytes Keywords: Immunochemistry, Multicellular systems Image BiTE secretion from in situ-programmed myeloid cells results in tumor-retained pharmacology Publication Year: 2022 Country: USA PMID: PMC8840964 Publication: J Control Release. 2022;342:14-25. doi:10.1016/j.jconrel.2021.12.029 Institute: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. Comparative Pathology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. Experimental Histopathology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. Tidal Therapeutics (A Sanofi Company), 270 Albany St, Cambridge, MA 02139, USA. Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, WA 98195, USA. Department of Bioengineering and Molecular Engineering & Sciences Institute, University of Washington, Seattle 98195, WA, USA. Instrument: BOND RX Authors: Hao S, Inamdar VV, Sigmund EC, et al. Study Goals: This study developed targeted nanocarriers that can deliver in vitro-transcribed mRNA encoding BiTEs to host myeloid cells - a cell type that is actively recruited into the tumor microenvironment. We demonstrate in an immunocompetent mouse model of ovarian cancer, that infusion of these nanoparticles directs BiTE expression to tumor sites, which reshapes the microenvironment from suppressive to permissive and triggers disease regression without systemic toxicity. Keywords: Bi-specific T-cell engagers (BiTEs); In situ gene therapy; Nanotechnology. Image Semiquantitative Methods for GFP Immunohistochemistry and In Situ Hybridization to Evaluate AAV Transduction of Mouse Retinal Cells Following Subretinal Injection Publication Year: 2022 Country: USA PMID: 33167778 Publication: Toxicol Pathol. 2021;49(3):537-543. doi:10.1177/0192623320964804 Institute: Covance Laboratories Inc., Madison, WI, USA Instrument: BOND RX Authors: Bondarenko G, Sorden SD, Christian BJ, Webster S, Sharma AK. Study Goals: The goal of this study was to develop methods for the evaluation of green fluorescent protein (GFP) and GFP transcript biodistribution in paraformaldehyde-fixed paraffin-embedded (PFPE) eye sections to assess the effectiveness of Adeno-associated virus (AAV) gene delivery in an experimental ocular toxicity study. Keywords: adeno-associated virus vector, green fluorescent protein, immunohistochemistry, in situ hybridization, ocular toxicology, retina, gene therapy Image CAR RNA FISH assay to study functional and spatial heterogeneity of chimeric antigen receptor T cells in tissue Publication Year: 2021 Country: USA PMID: N/A Publication: Scientific Reports. 2021;11(1). doi:10.1038/s41598-021-96979-0 Institute: Fred Hutchinson Cancer Research Center, University of Washington, Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research Institute Instrument: BOND RX Authors: Eichholz K, Li AZ, Diem K, Jensen MC, Zhu J, Corey L. A Study Goals: A CAR RNA FISH histo-cytometry platform combined with a random reaction seed image analysis algorithm to quantitate spatial distribution and in vivo functional activity of a CAR T cell population at a single cell resolution for preclinical models. Keywords: BOND RX, Chimeric antigen receptor, (CAR) T, CAR RNA FISH, histo-cytometry Image A non-clinical comparative study of IL-23 antibodies in psoriasis Publication Year: 2021 Country: USA PMID: 34460338 Publication: mAbs. 2021;13(1). doi:10.1080/19420862.2021.1964420 Institute: Abbvie Bioresearch Center, Worcester Instrument: BOND RX Authors: Zhou L, Wang Y, Wan Q, et al. Study Goals: To investigate if four clinically approved antibodies targeting IL-23 differ in affinity and binding epitope Keywords: BOND RX, IL-23, IL-12, psoriasis, autoimmune disease, risankizumab, guselkumab, tildrakizumab, ustekinumab Image Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis. Publication Year: 2021 Country: UK PMID: PMC8187652 Publication: Nature Communications. 2021;12(1). doi:10.1038/s41467-021-23717-5 Institute: Cancer Research UK Beatson Institute, Glasgow Instrument: BOND RX Authors: Leach JDG, Vlahov N, Tsantoulis P, et al. Study Goals: To study a mouse model of right-sided colon cancer driven by oncogenic BRAF and loss of epithelial TGFβ-receptor signalling Keywords: BOND RX, colorectal cancer, oncogenic BRAF, epithelial TGFβ-receptor signaling, RNAscope, Multiplex Image Feasibility of administering human pancreatic cancer chemotherapy in a spontaneous pancreatic cancer mouse model. Publication Year: 2021 Country: USA PMID: PMC8848646 Publication: BMC Cancer. 2022;22(1). doi:10.1186/s12885-022-09255-3 Institute: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX Instrument: BOND RX Authors: Delahoussaye AM, Abi Jaoude J, Green M, et al. Study Goals: To demonstrate the utility and feasibility of clinically relevant mFOLFIRINOX and gemcitabine/nab-paclitaxel in preclinical models of pancreatic cancer. Keywords: BOND RX, Gemcitabine; KPC mice; Nab-paclitaxel; Pancreatic cancer; SBRT; mFOLFIRINOX Image Stemness-Associated Markers Are Expressed in Extracranial Arteriovenous Malformation. Publication Year: 2021 Country: New Zealand PMID: PMC8017302 Publication: Frontiers in Surgery. 2021;8. doi:10.3389/fsurg.2021.621089 Institute: Gillies McIndoe Research Institute, Wellington Instrument: BOND RX Authors: Luke Krishnan CS, Brasch HD, Patel J, et al. Study Goals: Investigated the presence and expression pattern of OCT4, SOX2, NANOG, KLF4, and c-MYC in extracranial AVM Keywords: BOND RX Image Detection of engineered T cells in FFPE tissue by multiplex in situ hybridization and immunohistochemistry. Publication Year: 2020 Country: USA PMID: 33383062 Publication: J Immunol Methods. 2021;492:112955. doi:10.1016/j.jim.2020.112955 Institute: Immunopathology Lab Experimental Histopathology Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center Department of Immunology, University of Washington School of Medicine Department of Medicine, University of Washington Instrument: BOND RX Authors: Wright JH, Huang LY, Weaver S, et al. Study Goals: This new method provides the ability to mark the cells by ISH, and simultaneously stain for cell-associated proteins to immunophenotype CAR/TCR modified T cells within tumors, as well as assess potential roles of these cells in on-target/off-tumor toxicity in other tissue. Keywords: CAR-T; Immunohistochemistry; Immunophenotyping; TCR-T; WPRE; in situ hybridization. For Research Use Only. Not for use in diagnostic procedures. The content, including webinars, training presentations and related materials is intended to provide general information regarding particular subjects of interest to health care professionals and is not intended to be, and should not be construed as, medical, regulatory or legal advice. The views and opinions expressed in any third-party content reflect the personal views and opinions of the speaker(s)/author(s) and do not necessarily represent or reflect the views or opinions of Leica Biosystems, its employees or agents. Any links contained in the content which provides access to third party resources or content is provided for convenience only. For the use of any product, the applicable product documentation, including information guides, inserts and operation manuals should be consulted. Copyright © 2024 Leica Biosystems division of Leica Microsystems, Inc. and its Leica Biosystems affiliates. All rights reserved. LEICA and the Leica Logo are registered trademarks of Leica Microsystems IR GmbH.
