Fully Automated Workflows for High Plex Multi-omic Profiling with GeoMx® Digital Spatial Profiler and BOND RX/ BOND RXm Research Stainer Nicholas Confuorto MBA Senior Director Global Field Applications, Nanostring Technologies NanoString’s GeoMx® DSP allows for the characterization of spatial distribution and abundance of proteins and RNA with morphological context. This extends the ability for enhanced translational research in many areas including immunology, oncology, and neuropathology with downstream analysis of analyte abundance by nCounter or Next Generation Sequencing. Learning Objectives Describe four multi-omics analysis areas (RNA and Protein analysis) that a spatial solution can impact Identify three ways spatial profiling helps investigators answer research questions (Geometric, segmentation, etc.) Explain three workflow improvements that may be achieved by fully automating GeoMx RNA assays on the BOND RX To enhance both throughput and reproducibility, we recently have developed a fully automated sample processing RNA workflow for use with the BOND RX fully automated research stainer from Leica Biosystems. This workflow on the BOND RX allows a 4-fold increase in sample processing with minimal hands-on time. Additionally, through NanoString’s partnership with Illumina, automated secondary analysis has been enabled for the NextSeq 1000/2000, thereby further enabling a truly automated end-to-end workflow. For Research Use Only. Not for Use in Diagnostic Procedures. About the presenter Nicholas Confuorto , MBA Senior Director Global Field Applications, Nanostring Technologies Nick Confuorto is a Senior Director Global Field Applications at Nanostring Technologies where he is responsible for leading the development and execution of the strategic plan for the GeoMx Digital Spatial Profiling (DSP) business unit. Prior to joining Nanostring, Nick held several commercial roles across the Life Sciences industry with experience in bringing to market new capabilities in the Imaging, Flow Cytometry, and Mass Spectrometry fields. Nick has a strong passion for introducing cutting edge technologies that can accelerate Translational Research with the ultimate promise of benefiting patient care through precision medicine. Related Content Implementation of Fully Automated BOND RX Protocol for NanoString's GeoMx Assay Morphology Driven High-Plex Spatial Analysis of Tissue Microenvironments Leica Biosystems content is subject to the Leica Biosystems website terms of use, available at: Legal Notice. The content, including webinars, training presentations and related materials is intended to provide general information regarding particular subjects of interest to health care professionals and is not intended to be, and should not be construed as, medical, regulatory or legal advice. The views and opinions expressed in any third-party content reflect the personal views and opinions of the speaker(s)/author(s) and do not necessarily represent or reflect the views or opinions of Leica Biosystems, its employees or agents. Any links contained in the content which provides access to third party resources or content is provided for convenience only. For the use of any product, the applicable product documentation, including information guides, inserts and operation manuals should be consulted. Copyright © 2024 Leica Biosystems division of Leica Microsystems, Inc. and its Leica Biosystems affiliates. All rights reserved. LEICA and the Leica Logo are registered trademarks of Leica Microsystems IR GmbH. RELATED PRODUCTS BOND RX Fully Automated Research Stainer BOND RXm RELATED TAGS AND TOPICS Research Stainer, Digital, Spatial, RNA RELATED CONTENT Implementation of Fully Automated BOND RX Protocol for NanoString's GeoMx Assay Morphology Driven High-Plex Spatial Analysis of Tissue Microenvironments Contact Our Product Expert Now If you have viewed this educational webinar or training and would like to apply for continuing education credits with your certifying organization, please download the form to assist you in adding self-reported educational credits to your transcript. Apply for self-reported educational credits Subscribe to our mailing list to learn about our upcoming symposiums and new research-focused product launches. Subscribe today! SHARE Facebook Twitter LinkedIn Email