Home • Life Sciences and Research Solutions • Cell IDx Cell IDx High-throughput multiplex biomarker tissue profiling UltraPlex technology allows multiplex chromogenic and fluorescent staining of tissues and can be incorporated into advanced staining workflows. Contact Us Our Technology The new Leica Biosystems offering is optimal for research histopathology labs that seek to benefit from multiplexing IHC or IF for low-plex research applications. The Cell IDx portfolio by Leica Biosystems is a high throughput, low-plex solution that enables the custom detection of multiple primary antibodies from any species on the BOND RX. Unlike high-plex exploratory experiments, the unique Tag technology allows for targeted experiments to generate spatial information in days rather than weeks. Fluorescent & Chromogenic Multiplex IHC Staining Technology UltraPlex fluorescent multiplex immunohistochemistry and chromogenic multiplex immunohistochemistry comprise a paradigm-shifting technology that addresses the needs of precision medicine for multiplex IHC detection of proteins on tissues. Cell IDx has developed a proprietary, Tag-based technology to address the need for unrestricted, simple, rapid, and simultaneous detection of multiple biomarkers in any immunoassay. The underpinnings of the technology comprise novel Tag design and their detection with high affinity anti-Tag antibodies. Initially, we have directed our UltraPlex technology to the development of fluorescent multiplex IHC and chromogenic multiplex IHC tissue-based assays. Methods for chromogenic and fluorescent detection of multiple markers have long been an unmet need. Our UltraPlex technology presents solutions to both assays overcoming many limitations. Image UltraPlex Multiplex IHC and UltraTag Labeling Solutions Enable Translational and Preclinical Tissue Biomarker Profiling. UltraPlex multiplex IHC is a simple, fast, and fully automated multiplex staining technology. UltraPlex reagents are offered kitted for optimal immunofluorescent or brightfield chromogenic staining. The UltraTag labeling solutions allow for custom conjugation of your selected antibody. Generate beautiful images and data on biomarker expression and spatial localization of key cell subtypes using BOND RX, RXm staining system, Aperio VERSA, and Aperio GT 450 scanner. Image UltraPlex: Human Fluorescent Panels Our state of the art UltraPlex fluorescent multiplex IHC tagging technology enables identification, quantitation and spatial biomarker profiling of immune subsets in human FFPE tissue sections – all in a few hours on a single slide. Learn More Image UltraPolymer™ HRP Detection UltraPolymer anti-species-HRP secondary detection reagents are fully optimized on the BOND RX for IHC, and combine high sensitivity with low background. Learn More Image Chromogens & IHC Reagents Cell Palette Chromogens are highly sensitive chromogen substrates optimized for use in IHC staining with HRP- and AP- labeled detection reagents. A highly effective purple hematoxylin counterstain is also available. Learn More Image UltraPlex: Human Chromogenic Multiplex Panels Our chromogenic multiplex IHC technology uses our proprietary UltraPlex tagging system to allow simultaneous staining using cocktails of antibodies. Combined with a single antigen retrieval step and using Leica Biosystems BOND RX / RXm autostainers and Aperio brightfield scanners, this simple, rapid chromogenic multiplex staining allows out of the box access to brilliant chromogenic biomarker profiling of tissue sections. Learn More Image UltraTag Multiplex Labeling Kits UltraTag labeling kits allow you to transform your great IHC antibodies into fluorescent or chromogenic multiplex IHC staining panels. Choose the number of kits you require (1 per antibody), and then rapidly transform your IHC antibodies into 4-color fluorescent multiplex, or 3-color chromogenic multiplex immunohistochemistry panels. UltraTag kits efficiently label 50ug @ 1.0mg/ml of high-affinity, purified antibody in ~ 2 hours. Learn More Image UltraPlex: Mouse Fluorescent and Chromogenic Multiplex Our state-of-the-art UltraPlex fluorescent and chromogenic multiplex tagging technology enables identification, quantitation, and spatial biomarker profiling in mouse FFPE tissue sections - all in a few hours on a single slide. Learn More Image Gallery Image Tonsil-CP01A Image Colon-CP02A Image Lung-CP03A Image Bladder-HI01A Image Bladder-HI02A Image Rectum-HI03A Image Bladder-HI04A Image Lymph-Node-HI05A Image Lymph-Node-HI06A Visit Our Interactive Image Gallery Image Educational Resources Image Chromogenic Multiplex Biomarker Profiling of Human FFPE Tissues Using UltraPlex Technology Learn More Image Multiplex Immunofluorescence Profiling of Tumor Biopsies Using UltraPlex mxIF Technology Learn More Featured Products Image BOND RX Find Breakthroughs Faster with the Freedom to Discover LEARN MORE Image BOND RXm Helping academic researchers achieve more: BOND RXm – Fully Automated Advanced Staining LEARN MORE Image Aperio GT 450 Fast-Forward to Next Generation Imaging LEARN MORE Image Aperio VERSA Delivering Excellence in IHC, ISH and Fluorescent Tissue-Based Research including Multiplex Whole Slide Scanning LEARN MORE For Research Use Only. Not for use in diagnostic procedures.
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