Geoffrey Rolls

In this fourth part of the Fixation and Fixatives series, we look at some of the many popular and traditional fixative solutions that have been used in histology for the last 100 years. This part has an overview of proprietary solutions and...

As well as formaldehyde and glutaraldehyde, discussed previously, a number of other reagents have been used for fixation, sometimes in simple solution but often combined with other agents in the form of compound fixatives. The more important of these are...

In this final part of the Fixation and Fixatives series, we look at practical ways to optimize fixation quality, discuss how heat effects fixation, and finish with an introduction to the relatively new field of microwave fixation.

Routine (or H&E) and special stains allow us to visualize otherwise transparent tissue under a microscope and are critical for tissue-based diagnosis.

This second part of the Fixation and Fixatives series covers the factors that influence the rate and effectiveness of tissue fixation as well as looking at two common fixatives: formaldehyde (histology) and glutaraldehyde (ultrastructural electron microscopy...

An introduction to the preparation of specimens for microscopy in the histopathology laboratory.

From time to time, in all histopathology laboratories, paraffin blocks will be encountered that are difficult or even impossible to section.

This straightforward guide to good histology practice provides practical advice on best-practice techniques and simple ways to avoid common errors.